The Raiders punted following a third consecutive three-and-out, and safety Jim Leonhard’s strong return combined with a 15-yard facemask penalty gave Denver possession at their own 37-yard line.
Demaryius Thomas caught a pass on the first play of the drive, and an open-field cut along with a stiff arm helped him pick up 25 yards.
Another big play followed, as Willis McGahee rushed up the middle for 24 yards to the Oakland 14-yard line.
Two plays later, on a third down, Manning found running back Lance Ball wide open in the middle of the field, and Ball ran it in for a touchdown.
Ball’s score was Denver’s third touchdown of the half and Manning’s third touchdown pass of the game. It marks the 65th time Manning has thrown for a trio of scores in his career. Only Brett Favre (72) has more in NFL history.
The Broncos lead 31-6 inside the four-minute mark of the third quarter.
The drive took five plays to move 63 plays in 1:36 of game clock.