A three-and-out that featured linebacker Keith Brooking’s first sack since 2010 helped set up the Denver offense for its fifth touchdown drive of the game.
An 8-yard completion to tight end Virgil Green and a 9-yard completion to wideout Eric Decker helped get Denver moving.
A 15-yard defensive pass intereference call on a pass intended for tight end Jacob Tamme put Denver across midfield to the Denver 41-yard line.
A play later, Manning faked a handoff from the shotgun formation and lofted one for wideout Demaryius Thomas, who made a striding, over-the-shoulder catch to the K.C. 3-yard line.
Running back Lance Ball finished the drive off with a 3-yard touchdown run, his first of the season and second of his career.
After the score, Denver leads 35-3 with 1:04 remaining in the third quarter.
On the drive, Manning topped the 300-yard mark for the 72nd time of his career, extending an NFL record he already owns. It is the ninth time this season that Manning has topped that mark, which ties a career-best. In the game, Manning is 23-of-29 for 304 yards and three touchdowns, good for a passer rating of 144.8.
Thomas passed 100 yards receiving on the drive for the ninth time of his career and eighth time in the regular season. He has done so seven times in the 2012 season. It is the second straight week Thomas as topped 100 yards, as he has piled up seven catches on 122 yards in the game – the sixth-highest receiving yards total of his career.